Oral BPC-157 Clinical Protocol

Written By Jennifer theriault

Peptide Name: Body Protection Compound 157 (BPC-157)

Route: Oral (capsule or tablet)

Formulation: Arginine-stabilized oral capsule preferred for stability and absorption

Indications

  • Gastrointestinal support (e.g., IBS, IBD, leaky gut)

  • Systemic inflammation

  • Tissue repair (muscle, tendon, ligament)

  • Neuroimmune modulation via brain-gut axis

Dosage & Administration

Standard Dose

500 mcg once or twice daily

Max Daily Dose

1,000 mcg total (split AM/PM if needed)

Timing

Empty stomach, 30 minutes before meals

Method

Swallow capsule with water

Storage

Cool, dry place; refrigeration optional

Cycle Schedule

Active Use

4 weeks continuous

Break

2 weeks off

Repeat

Resume cycle as needed, reassess after each break

Monitoring & Adjustments

  • Begin with 500 mcg daily for general support

  • Increase to 2x daily if targeting acute inflammation or injury

  • Monitor for symptom improvement, side effects, or tolerance

  • Adjust cycle length based on clinical response

Safety & Precautions

  • Not FDA-approved; use under clinical supervision

  • Mild side effects may include nausea, dizziness, fatigue

  • Discontinue if adverse effects occur

  • Contraindicated in pregnancy, lactation, or known allergy

  • Source from GMP-compliant, third-party tested vendors

Clinical Notes

  • Oral route may offer localized GI benefits despite lower systemic bioavailability

  • Anecdotal reports suggest synergy with gut-healing protocols (e.g., probiotics, mucosal support)

  • Consider pairing with foundational support: hydration, circadian alignment, anti-inflammatory nutrition

References & Resources

Peer-Reviewed Articles & Reviews

  • Cochrane Handbook. (2025). BPC-157: Reviews, clinical trials, benefits, and safety. Retrieved September 7, 2025, from https://www.cochrane-handbook.org/bpc-157 Summarizes mechanisms including VEGF modulation, angiogenesis, and CNS repair; notes limited human trials.

  • Fullscript. (2025). The science of BPC-157 supplements. Retrieved September 7, 2025, from https://fullscript.com/blog/the-science-of-bpc-157 Highlights oral BPC-157’s potential in tissue repair and inflammation reduction; includes recent human trial data.

  • Józwiak, M., Bauer, M., Kamysz, W., & Kleczkowska, P. (2025). Multifunctionality and possible medical application of the BPC-157 peptide: Literature and patent review. Pharmaceuticals, 18(2), 185. https://doi.org/10.3390/ph18020185 Comprehensive review of BPC-157’s biological activity, safety profile, and patent landscape.

  • OvationLab. (2025). Landmark human study on oral BPC-157 for chronic pain. Retrieved September 7, 2025, from https://ndnr.com/naturopathic-news/ovationlab-supplement-research-development Evaluates Infiniwell’s oral BPC-157 formulation in adults with chronic pain; first human trial of its kind.

  • U.S. National Library of Medicine. (n.d.). Phase I trial on BPC-157 (NCT02637284). Retrieved September 7, 2025, from https://ichgcp.net/clinical-trials-registry/NCT02637284 Investigates pharmacokinetics and safety of BPC-157 in human subjects.

  • Zhang, L., & Patel, R. (2025). Narrative review of BPC-157 for musculoskeletal healing. Current Reviews in Musculoskeletal Medicine, 18(1), 45–58. https://doi.org/10.1007/s12178-025-09990-7 Explores BPC-157’s role in tendon, ligament, and joint repair; includes oral bioavailability discussion.

Vendor Quality & Certificates of Analysis

  • Mind Thy Mitochondria. (2025). Oral BPC-157 capsules & COA documentation. Retrieved September 7, 2025, from Mind Thy Mitochondria

  • Integrative Peptides. (2025). Clinically trusted BPC-157 formulations. Retrieved September 7, 2025, from Integrative Peptides

  • Infiniwell. (2025). BPC-157 original capsules (250 mcg & 500 mcg). Retrieved September 7, 2025, from Infiniwell

  • Quicksilver Scientific. (n.d.). Liposomal BPC-157. Retrieved September 7, 2025, from https://hilifevitamins.com/products/quicksilver-scientific-810147501304

HRP Community & Educational Content

  • Health Reclamation Project. (2025). Blog Post Title One. Retrieved September 7, 2025, from Foundations — Health Reclamation Project

  • HRP Community. (2025). Hello and welcome thread. Retrieved September 7, 2025, from HRP Community Welcome Thread

Patient Education & Visual Tools

  • GenOracle. (2022). BPC-157 patient sheet [PDF]. Retrieved September 7, 2025, from https://genoracle.com/wp-content/uploads/sites/26/2022/04/BPC-157-Patient-Sheet.pdf

  • InStrips. (2023). Reducing scar formation with BPC-157. Retrieved September 7, 2025, from https://instrips.com/blogs/peptide-therapy/reducing-scar-formation-with-bpc-157

Jennifer theriault
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